Aox1 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comAox1 Polyclonal Antibody for Rat(Rattus norvegicus)

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Aox1 (Gene name),

Aldehyde oxidase 1 (Protein name ), AOXA_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aox1(Ao);

Protein name:

Aldehyde oxidase 1;

Alternative:

1.17.3.-;Azaheterocycle hydroxylase 1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer.

Function:

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. Is a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also catalyzes nitric oxide (NO) production; under anaerobic conditions, reduces nitrite to NO with NADH or aldehyde as electron donor, but under aerobic conditions, NADH is the preferred substrate. These reactions may be catalyzed by several isozymes. May play a role in adipogenesis.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1333

Sequence:

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1333:

LTPEKIRMAC | EDKFTKMIPR | DEPGSYVPWN | IPV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01315

KEGG:

rno:54349

UniGene:

Rn.15681

SMR:

Q9Z0U5

Uniprot:

Q9Z0U5

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ELISA Kit for Rat Aldehyde oxidase 1

Cat.:

E5988m

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96T

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ELISA Kit for Rat Aldehyde oxidase 1

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ELISA Kit for Rat Aldehyde oxidase 1

Cat.:

E5988r

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96T

ELISA Kit for Rat Aldehyde oxidase 1

Cat.:

E5988b

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96T

ELISA Kit for Rat Aldehyde oxidase 1

Cat.:

E5988h

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Packing:

96T

CLIA Kit for Rat Aldehyde oxidase 1

Cat.:

U5988r

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Packing:

96T

CLIA Kit for Rat Aldehyde oxidase 1

Cat.:

U5988m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Aldehyde oxidase 1

Cat.:

U5988b

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MSDS:

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Packing:

96T

CLIA Kit for Rat Aldehyde oxidase 1

MSDS:

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CLIA Kit for Rat Aldehyde oxidase 1

Cat.:

U5988h

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96T

Polyclonal Antibody for Rat Aldehyde oxidase 1

Cat.:

P5988Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Aldehyde oxidase 1

Cat.:

P5988Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Aldehyde oxidase 1

Monoclonal Antibody for Rat Aldehyde oxidase 1

Protein for Rat Aldehyde oxidase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1). Differences in redox status may distinguish male and female forms of hepatic APX."
Wright R.M. , Clayton D.A. , Riley M.G. , McManaman J.L. , Repine J.E.
J. Biol. Chem.274:3878-3886(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;BLOCKAGE OF N-TERMINUS;HOMODIMER;VARIANTS 119-ALA-ARG-120; THR-649; LEU-1276 AND ARG-1315
strain: Sprague-Dawley.
tissue: Liver.
2.

"In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver."
Rashidi M.R. , Smith J.A. , Clarke S.E. , Beedham C.
Drug Metab. Dispos.25:805-813(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AZAHETEROCYCLE OXIDASE;CATALYTIC ACTIVITY;ENZYME REGULATION;KINETIC PARAMETERS
3.

"Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues."
Kundu T.K. , Hille R. , Velayutham M. , Zweier J.L.
Arch. Biochem. Biophys.460:113-121(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SUPEROXIDE PRODUCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;HOMODIMER;COFACTOR
4.

"Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite."
Li H. , Kundu T.K. , Zweier J.L.
J. Biol. Chem.284:33850-33858(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NITRIC OXIDE PRODUCTION;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
5.

"Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression."
Kurosaki M. , Bolis M. , Fratelli M. , Barzago M.M. , Pattini L. , Perretta G. , Terao M. , Garattini E.
Cell. Mol. Life Sci.70:1807-1830(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF PARALOGS
6.

"Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids."
Hamzeh-Mivehroud M. , Rahmani S. , Rashidi M.R. , Hosseinpour Feizi M.A. , Dastmalchi S.
Xenobiotica43:661-670(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION

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